Diffusion Tensor Imaging of Parkinson’s Disease, Atypical Parkinsonism and Essential Tremor
Identifieur interne : 000A27 ( Main/Exploration ); précédent : 000A26; suivant : 000A28Diffusion Tensor Imaging of Parkinson’s Disease, Atypical Parkinsonism and Essential Tremor
Auteurs : Janey Prodoehl [États-Unis] ; Hong Li [États-Unis] ; Peggy J. Planetta [États-Unis] ; Christopher G. Goetz [États-Unis] ; Kathleen M. Shannon [États-Unis] ; Ruth Tangonan [États-Unis] ; Cynthia L. Comella [États-Unis] ; Tanya Simuni [États-Unis] ; Xiaohong Joe Zhou [États-Unis] ; Sue Leurgans [États-Unis] ; Daniel M. Corcos [États-Unis] ; David E. Vaillancourt [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Anisotropy, Basal Ganglia (pathology), Cerebellum (pathology), Diffusion Tensor Imaging, Essential Tremor (diagnosis), Female, Humans, Male, Middle Aged, Multiple System Atrophy (diagnosis), Parkinson Disease (diagnosis), ROC Curve, Supranuclear Palsy, Progressive (diagnosis).
- MESH :
- diagnosis : Essential Tremor, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- pathology : Basal Ganglia, Cerebellum.
- Aged, Analysis of Variance, Anisotropy, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, ROC Curve.
Abstract
Diffusion tensor imaging could be useful in characterizing movement disorders because it non-invasively examines multiple brain regions simultaneously. We report a multi-target imaging approach focused on the basal ganglia and cerebellum in Parkinson’s disease, parkinsonian variant of multiple system atrophy, progressive supranuclear palsy, essential tremor, and healthy controls. Seventy-two subjects were studied with a diffusion tensor imaging protocol at 3 Tesla. Receiver operating characteristics analysis was performed to directly compare groups. Sensitivity and specificity values were quantified for control vs. movement disorder (92% sensitivity, 88% specificity), control vs. parkinsonism (93% sensitivity, 91% specificity), Parkinson’s disease vs. atypical parkinsonism (90% sensitivity, 100% specificity), Parkinson’s disease vs. multiple system atrophy (94% sensitivity, 100% specificity), Parkinson’s disease vs. progressive supranuclear palsy (87% sensitivity, 100% specificity), multiple system atrophy vs. progressive supranuclear palsy (90% sensitivity, 100% specificity), and Parkinson’s disease vs. essential tremor (92% sensitivity, 87% specificity). The brain targets varied for each comparison, but the substantia nigra, putamen, caudate, and middle cerebellar peduncle were the most frequently selected brain regions across classifications. These results indicate that using diffusion tensor imaging of the basal ganglia and cerebellum accurately classifies subjects diagnosed with Parkinson’s disease, atypical parkinsonism, and essential tremor and clearly distinguishes them from control subjects.
Url:
DOI: 10.1002/mds.25491
PubMed: 23674400
PubMed Central: 3748146
Affiliations:
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Planetta</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Tangonan, Ruth" sort="Tangonan, Ruth" uniqKey="Tangonan R" first="Ruth" last="Tangonan">Ruth Tangonan</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="2"><nlm:aff id="A6">Parkinson’s Disease and Movement Disorders Center, Northwestern University, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Parkinson’s Disease and Movement Disorders Center, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Xiaohong Joe" sort="Zhou, Xiaohong Joe" uniqKey="Zhou X" first="Xiaohong Joe" last="Zhou">Xiaohong Joe Zhou</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Radiology, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Radiology, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Department of Bioengineering, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Bioengineering, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A10">Center for MR Research, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Center for MR Research, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Preventive Medicine, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Preventive Medicine, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A11">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A8">Department of Bioengineering, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Bioengineering, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A9">Department of Psychology, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Psychology, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A12">Department of Neurology, University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Biomedical Engineering, University of Florida, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Anisotropy</term><term>Basal Ganglia (pathology)</term><term>Cerebellum (pathology)</term><term>Diffusion Tensor Imaging</term><term>Essential Tremor (diagnosis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (diagnosis)</term><term>Parkinson Disease (diagnosis)</term><term>ROC Curve</term><term>Supranuclear Palsy, Progressive (diagnosis)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term><term>Cerebellum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Anisotropy</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>ROC Curve</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P2">Diffusion tensor imaging could be useful in characterizing movement disorders because it non-invasively examines multiple brain regions simultaneously. We report a multi-target imaging approach focused on the basal ganglia and cerebellum in Parkinson’s disease, parkinsonian variant of multiple system atrophy, progressive supranuclear palsy, essential tremor, and healthy controls. Seventy-two subjects were studied with a diffusion tensor imaging protocol at 3 Tesla. Receiver operating characteristics analysis was performed to directly compare groups. Sensitivity and specificity values were quantified for control vs. movement disorder (92% sensitivity, 88% specificity), control vs. parkinsonism (93% sensitivity, 91% specificity), Parkinson’s disease vs. atypical parkinsonism (90% sensitivity, 100% specificity), Parkinson’s disease vs. multiple system atrophy (94% sensitivity, 100% specificity), Parkinson’s disease vs. progressive supranuclear palsy (87% sensitivity, 100% specificity), multiple system atrophy vs. progressive supranuclear palsy (90% sensitivity, 100% specificity), and Parkinson’s disease vs. essential tremor (92% sensitivity, 87% specificity). The brain targets varied for each comparison, but the substantia nigra, putamen, caudate, and middle cerebellar peduncle were the most frequently selected brain regions across classifications. These results indicate that using diffusion tensor imaging of the basal ganglia and cerebellum accurately classifies subjects diagnosed with Parkinson’s disease, atypical parkinsonism, and essential tremor and clearly distinguishes them from control subjects.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></region><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><name sortKey="Li, Hong" sort="Li, Hong" uniqKey="Li H" first="Hong" last="Li">Hong Li</name><name sortKey="Planetta, Peggy J" sort="Planetta, Peggy J" uniqKey="Planetta P" first="Peggy J." last="Planetta">Peggy J. Planetta</name><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><name sortKey="Tangonan, Ruth" sort="Tangonan, Ruth" uniqKey="Tangonan R" first="Ruth" last="Tangonan">Ruth Tangonan</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Zhou, Xiaohong Joe" sort="Zhou, Xiaohong Joe" uniqKey="Zhou X" first="Xiaohong Joe" last="Zhou">Xiaohong Joe Zhou</name><name sortKey="Zhou, Xiaohong Joe" sort="Zhou, Xiaohong Joe" uniqKey="Zhou X" first="Xiaohong Joe" last="Zhou">Xiaohong Joe Zhou</name><name sortKey="Zhou, Xiaohong Joe" sort="Zhou, Xiaohong Joe" uniqKey="Zhou X" first="Xiaohong Joe" last="Zhou">Xiaohong Joe Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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